LSU Superfund Research: Environmentally Persistent Free Radicals
Hazardous substances at Superfund sites are frequently associated with particulate matter (PM), either in contaminated soils or sediments, emissions from treatment facilities, or dust from remediation or containment activities. Our research focuses on newly-identified pollutant-particle systems, including environmentally persistent free radicals, that may form from the combination of pollutants and particulate matter, and their effect on respiratory and cardiac health. The ultimate goal of the research is to protect human health by providing information to be used in risk-based decisions on treatment options for Superfund wastes.
The LSU Superfund Research Program is supported by a Multiproject Center Grant (P42ES013648 ) from the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP). These grants fund a combination of biomedical and environmental science and engineering research projects as well as cores dedicated to research support, training, community engagement and administration and research translation.
The LSU Superfund Research Program consists of six research projects, four research support cores and administrative, research translation, community outreach, and training cores.
Our Center is made of up five integrated projects that focus on environmentally persistent free radicals. Two projects are biomedical research projects and three project involve environmental science and engineering research:
- Project 1: Environmentally Persistent Free Radicals Alter Pulmonary Immunologic Homeostasis (Principal Investigator: Stephania Cormier)
- Project 2: Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure (Principal Investigator: Tammy Dugas)
- Project 3: Hazardous Waste Thermal Treatment and Community Exposure to Environmentally Persistent Free Radicals (Principal Investigator: Jennifer Richmond-Bryant)
- Project 4: Activation, Sensing, and Prevention of Formation of EPFRs in Thermal Treatment of Superfund Wastes (Principal Investigator: Slawo Lomnicki)
- Project 5: Microstructural Pathway of EPFR Formation and Their Decay Mechanisms (Principal Investigator: Phillip Sprunger)
Our Center has six support cores that contribute to our research activities in different ways:
- Administrative Core (Principal Investigator: Stephania Cormier)
- Data Management and Analysis Core (Principal Investigator: Donald Mercante)
- Community Engagement Core (Principal Investigator: Margaret Reams)
- Research Experience and Training Coordination Core (Principal Investigator: Tammy Dugas)
- Materials Core (Principal Investigator: Lavrent Khachatryan)
- Inhalation Toxicology Core (Principal Investigator: Alexandra Noel)
History of the LSU Superfund Research Center
The LSU Superfund Research Center was founded by Barry Dellinger and has been previously funded by the NIEHS. The projects and cores from the previous funding cycle are listed below.
- Formation and Reactions of Environmentally Persistent Free Radicals in Thermal Processing of Superfund Wastes (Project 1)
- Environmentally Persistent Free Radicals Alter Pulmonary Immunologic Homeostasis (Project 2)
- Environmentally Persistent Free Radicals in Contaminated Soils (Project 3)
- Environmentally Persistent Free Radicals Increase Cardiac Vulnerability to Ischemia (Project 4)
- Pollutant-Particle Systems and Xenobiotic Bioactivation (Project 5)
- Structure and Properties of Metal Oxide Particle-Adsorbate Systems (Project 6)