Brent Stanfield

Brent Stanfield

Assistant Professor (Research)

Department of Pathobiological Sciences

LSU School of Veterinary Medicine
Louisiana State University
Baton Rouge, LA 70803

EMAIL DR. STANFIELD

Education

Post-doctoral fellowship, Duke University

PhD, Louisiana State University

BSc, University of North Carolina

Research Interest

My lab focuses on understanding the role of cytomegalovirus in the pathogenesis of various cancers. We utilize recombinant murine cytomegalovirus and mouse models of metastatic breast cancer to address questions regarding the mechanism by which cytomegalovirus alters the tumor microenvironment to promote the angiogenesis and metastasis of the primary tumor in-vivo. Additionally, we are interested in ways to utilize viral gene products and the T cell expansion that occurs naturally during cytomegalovirus infection to develop the next generation of immunotherapies for the treatment of cancer. 

Teaching Interest

I am interested in teaching molecular biology principals and techniques, immunology relating to viruses and vaccines, and herpes virology. 

Clinical Interest

I am interested to collaborate with clinical veterinarians and pathologists to identify novel tumor associated herpes viruses in the diverse animal populations admitted here at LSU-SVM. Additionally, I am interested in utilizing patient samples to better understand the pathology of acute respiratory distress syndrome in dogs.  

Awards & Honors

2021, Faculty Opinions: Associate Faculty Member Travel Grant Critical Care & Emergency Medicine Faculty 

2018, Viral Oncology Training Grant Trainee, Duke University Medical Center Department of Molecular Genetics and Microbiology (Renewal) 

2017, Best Dissertation Award for 2016, Louisiana State University School of Veterinary Medicine 

2017, Viral Oncology Training Grant Trainee, Duke University Medical Center Department of Molecular Genetics and Microbiology 

2016, Hannelore and Johannes Storz student travel award, Louisiana State University 
School of Veterinary Medicine Department of Pathobiological Sciences 

2015, 3rd Place Graduate Student Poster, SE Regional IDeA Conference, Biloxi, Mississippi 

2015, Hannelore and Johannes Storz student travel award, Louisiana State University 
School of Veterinary Medicine Department of Pathobiological Sciences 

2012, Research Fellowship, Louisiana Board of Regents 

Publications

Stanfield BA and M. A. Luftig (2017). Recent advances in understanding Epstein-Barr virus. F1000Res. 2017 Mar 29;6:386. doi: 10.12688/f1000research.10591.1. eCollection 2017. Review. PubMed PMID: 28408983; PubMed Central PMCID: PMC5373418. https://pubmed.ncbi.nlm.nih.gov/28408983/

Liu SA, Stanfield BA, Chouljenko VN, Naidu S, Langohr I, Del Piero F, Roy AA, Kousoulas KG (2017). Intramuscular Immunization of Mice with the Live-Attenuated Herpes Simplex Virus 1 Vaccine Strain VC2 Expressing Equine Herpesvirus 1 (EHV-1) Glycoprotein D Generates Anti-EHV-1 Immune Responses in Mice. J Virol. 2017 May 26;91(12). pii: e02445-16. doi: 10.1128/JVI.02445-16. Print 2017 Jun 15. PubMed PMID: 28404844; PubMed Central PMCID: PMC5446645. https://pubmed.ncbi.nlm.nih.gov/28404844/

Stanfield BA, Rider PJF, Caskey J, Del Piero F, Kousoulas KG. Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses. Vaccine. 2018 Apr 11. pii: S0264-410X(18)30444-4. doi: 10.1016/j.vaccine.2018.03.075. [Epub ahead of print] PubMed PMID: 29655629. https://pubmed.ncbi.nlm.nih.gov/29655629/

Naidu, SK, Nabi R, Cheemaria NR, Stanfield BA, Rider PJ, Jambunathan N, Chouljenko VN, Carter R, Del Piero F, Langohr I, Kousoulas KG (2020) Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis. PLoS One 2020 Feb 07. Doi: 10.1371/journal.pone.0228252 PMID: 32027675 https://pubmed.ncbi.nlm.nih.gov/32027675/

Stanfield BA, Purves T, Palmer S, Sullenger B, Welty-Wolf K, Haines K, Agarwal S, Kasotakis G. IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages. PLoS One. 2021 Jan 20;16(1):e0245169. doi: 10.1371/journal.pone.0245169. PMID: 33471802. https://pubmed.ncbi.nlm.nih.gov/33471802/

Van Orden K, Santos J, Stanfield B, Frost LS, Ruditsky A, Foster A, Brahmbhatt TS, Burke PA, Fernandez-Moure J, Haines K, Agarwal S, Kasotakis G. Bovine versus porcine acellular dermal matrix for abdominal wall herniorrhaphy or bridging. Eur J Trauma Emerg Surg. 2021 Mar 13. doi: 10.1007/s00068-021-01641-z. Epub ahead of print. PMID: 33712893. https://pubmed.ncbi.nlm.nih.gov/33712893/

Kasotakis G, Stanfield B, Haines K, Vatsaas C, Alger A, Vaslef SN, Brooks K, Agarwal S. Acute Respiratory Distress Syndrome (ARDS) after trauma: Improving incidence, but increasing mortality. J Crit Care. 2021 Aug;64:213-218. doi: 10.1016/j.jcrc.2021.05.003. Epub 2021 May 13. PMID: 34022661. https://pubmed.ncbi.nlm.nih.gov/34022661/

Panthi S, Schmitt PT, Lorenz FJ, Stanfield BA, Schmitt AP. Paramyxovirus-like particles as protein delivery vehicles. J Virol. 2021 Aug 11:JVI0103021. doi: 10.1128/JVI.01030-21. Epub ahead of print. PMID: 34379508. https://pubmed.ncbi.nlm.nih.gov/34379508/

Stanfield BA, Kousoulas KG, Fernandez A, Gershburg E. Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses. Viruses. 2021 Aug 18;13(8):1637. doi: 10.3390/v13081637. PMID: 34452501; PMCID: PMC8402837. https://pubmed.ncbi.nlm.nih.gov/34452501/

Bonavita CM, White TM, Stanfield BA, Cardin RD. Characterization of murine cytomegalovirus infection and induction of calcification in Murine Aortic Vascular Smooth Muscle Cells (MOVAS). J Virol Methods. 2021 Nov;297:114270. doi: 10.1016/j.jviromet.2021.114270. Epub 2021 Aug 27. PMID: 34461152. https://pubmed.ncbi.nlm.nih.gov/34461152/  

MYNCBI BIBLIOGRAPHY

Grant Funding

Previous, Private Funding, Ximus Biosciences, LLC., “The Effect of Pre-existing Immunity on the Delivery Efficacy of VLPs”, $3,857.00

Current, NIH Contract, “Mouse and Guinea Pig Models for Cytomegalovirus and Herpes Simplex Viruses”, Year 5 Funding, $137,097.00

Current, Pilot project, The Center of Pre-clinical Cancer Research COBRE, “Preclinical Testing of an Adenovirus Vectored Vaccine to treat CMV+ Breast Cancer”, $50,000.00