Weishan Huang
Associate Professor
Department of Pathobiological Sciences
LSU School of Veterinary Medicine
Louisiana State University
Baton Rouge, LA 70803
In the News
LSU VET MED SCHOLAR AWARDED RESEARCH PUBLICATION GRANT IN ENGINEERING, MEDICINE AND SCIENCE
Education
BS, Tsinghua University (China), 2008
MS, Pennsylvania State University, 2010
PhD, Cornell University, 2014
Research Interest
Huang lab studies the development and function of regulatory immunity and immune memory.
Teaching Interest
Virology and immunology
Awards & Honors
2022, LSU Alumni Association Rising Faculty Research Award
2021, AAI Careers in Immunology Fellowship (PI: Weishan Huang; Fellow: Michael McGee)
2021, Zoetis Award for Veterinary Research Excellence
2019, AAI Public Policy Fellowship
2018, Faculty Scholarship, Summer Institute on the Future of Graduate Studies at LSU
Publications
Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT., Mammadli, M; Huang, Weishan; Harris, R; Xiong, H; Weeks, S; May, A; Gentile, T; Henty-Ridilla, J; Waickman, A; August, A; Bah, A; Karimi, M, 2021, iScience , Volume: 24, Number: 4, Pages: 102286
Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT., Mammadli, M; Huang, Weishan; Harris, R; Sultana, A; Cheng, Y; Tong, W; Pu, J; Gentile, T; Dsouza, S; Yang, Q; Bah, A; August, A; Karimi, M, 2020, Frontiers in immunology , Volume: 11, Pages: 593863
TCR Signal Strength and Antigen Affinity Regulate CD8+ Memory T Cells., Solouki, S; Huang, Weishan; Elmore, J; Limper, C; Huang, F; August, A, 2020, Journal of immunology (Baltimore, Md. : 1950) , Volume: 205, Number: 5, Pages: 1217-1227
Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection., Huang, L; Ye, K; McGee, M; Nidetz, N; Elmore, J; Limper, C; Southard, T; Russell, D; August, A; Huang, Weishan, 2020, Frontiers in immunology , Volume: 10, Pages: 3103
Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery., Nidetz, N; McGee, M; Tse, L; Li , C; Cong, L; Li , Y; Huang, Weishan, 2019, Pharmacology & therapeutics , Pages: 107453
Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications., Solouki, S; August, A; Huang, Weishan, 2019, Pharmacology & therapeutics , Volume: 201, Pages: 39-50
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2., Cao, J; Sun, L; Aramsangtienchai, P; Spiegelman, N; Zhang, X; Huang, Weishan; Seto, E; Lin, H, 2019, Proceedings of the National Academy of Sciences of the United States of America , Volume: 116, Number: 12, Pages: 5487-5492
Thymic regulatory T cells arise via two distinct developmental programs., Owen, D; Mahmud, S; Sjaastad, L; Williams, J; Spanier, J; Simeonov, D; Ruscher, R; Huang, Weishan; Proekt, I; Miller, C; Hekim, C; Jeschke, J; Aggarwal, P; Broeckel, U; LaRue, R; Henzler, C; Alegre, M; Anderson, M; August, A; Marson, A; Zheng, Y; Williams, C; Farrar, M, 2019, Nature immunology , Volume: 20, Number: 2, Pages: 195-205
Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages., Huang, Weishan; Solouki, S; Carter, C; Zheng, S; August, A, 2018, Frontiers in immunology , Volume: 9, Pages: 2625
ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells., Huang, Weishan; Solouki, S; Koylass, N; Zheng, S; August, A, 2017, Nature communications , Volume: 8, Pages: 15871
Grant Funding
Modulation of TCR signaling for sustainable CAR-T therapy, NIH/NIGMS: LSU Center for Pre-Clinical Cancer Research, Principal Investigator, 06/2022-02/2023
Signaling regulation of immune homeostasis , MegaRobo, Principal Investigator, 01/2022-12/2031
Markers and regulation of regulatory CD8+ T cells during influenza-induced lung immunopathology, NIH/NIAID R01, Principal Investigator, 07/2021-06/2026
A rapid and sensitive technology for direct sensing of intact SARS-CoV-2 virions using designer DNA nanostructure probes and a smartphone fluorimeter, NIH/NIBIB R21, Co-Investigator, 09/2021-09/2023
Regulation of IL10 production in CD8+ T cells during flu infection by tyrosine kinase ITK, NIH/NIAID R01, Co-Investigator, 06/2018-05/2023
Detection and Automatic Privacy-Protected Contact Tracing System Designed for COVID-19, NIH/NIAAA U01, Co-Investigator, 12/2020-11/2022
ITK signaling in tissue resident memory T cell development and function in flu-associated pulmonary sequelae, AAI Careers in Immunology Fellowship, Principal Investigator, 09/2021-08/2022
Heterogeneity and molecular signatures of therapeutic T cells in allergic airway inflammation, NIH/NIAID R56, Principal Investigator, 12/2019-11/2021
Project 2: TCR signaling in IL-10 production by CD8+ T cells during influenza-induced lung immunopathology, NIH/NIGMS P20: LSU-Center for Lung Biology and Disease, Principal Investigator, 01/2019-08/2021, $770,778.00
GCN2 signaling in pathogenic and regulatory T cell development in allergic airway inflammation, NIH/NIAID R21, Principal Investigator, 06/2018-05/2021, $407,000.00
A novel murine model of allergic airway inflammation, NIH/NIAID R21, Co-Principal Investigator, 06/2018-05/2020, $443,292.00
Itk signaling and Type 1 regulatory T cell differentiation and function in allergic airway inflammation, NIH/NIAID R21, Co-Principal Investigator, 12/2017-11/2019, $431,021.00
ITK signaling in type 2 innate lymphoid cell-mediated pulmonary inflammation and fibrosis, LSU-SVM, Competitive Research Program (CORP), Principal Investigator, 06/2018-01/2019, $9,200.00
T cell signals in immune balance and host survival during T. gondii infection, NIH/NIGMS: LSU-Tulane Center for Experimental Infectious Disease and Research, Principal Investigator, 05/2018-01/2019, $50,000.00