Weishan Huang

Weishan Huang

Assistant Professor

Department of Pathobiological Sciences

LSU School of Veterinary Medicine
Louisiana State University
Baton Rouge, LA 70803

EMAIL DR. HUANG

Huang Lab

Education

PhD, Cornell University

 

Research Interest

Huang lab studies the development and function of regulatory immunity and immune memory.

 

Teaching Interest

Virology and immunology

 

Awards & Honors

2022, LSU Alumni Association Rising Faculty Research Award

2021, AAI Careers in Immunology Fellowship (PI: Weishan Huang; Fellow: Michael McGee)

2021, Zoetis Award for Veterinary Research Excellence

2019, AAI Public Policy Fellowship

2018, Faculty Scholarship, Summer Institute on the Future of Graduate Studies at LSU

 

Publications

Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT., Mammadli, M; Huang, Weishan; Harris, R; Xiong, H; Weeks, S; May, A; Gentile, T; Henty-Ridilla, J; Waickman, A; August, A; Bah, A; Karimi, M, 2021, iScience , Volume: 24, Number: 4, Pages: 102286

Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT., Mammadli, M; Huang, Weishan; Harris, R; Sultana, A; Cheng, Y; Tong, W; Pu, J; Gentile, T; Dsouza, S; Yang, Q; Bah, A; August, A; Karimi, M, 2020, Frontiers in immunology , Volume: 11, Pages: 593863

TCR Signal Strength and Antigen Affinity Regulate CD8+ Memory T Cells., Solouki, S; Huang, Weishan; Elmore, J; Limper, C; Huang, F; August, A, 2020, Journal of immunology (Baltimore, Md. : 1950) , Volume: 205, Number: 5, Pages: 1217-1227

Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection., Huang, L; Ye, K; McGee, M; Nidetz, N; Elmore, J; Limper, C; Southard, T; Russell, D; August, A; Huang, Weishan, 2020, Frontiers in immunology , Volume: 10, Pages: 3103

Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery., Nidetz, N; McGee, M; Tse, L; Li , C; Cong, L; Li , Y; Huang, Weishan, 2019, Pharmacology & therapeutics , Pages: 107453

Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications., Solouki, S; August, A; Huang, Weishan, 2019, Pharmacology & therapeutics , Volume: 201, Pages: 39-50

HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2., Cao, J; Sun, L; Aramsangtienchai, P; Spiegelman, N; Zhang, X; Huang, Weishan; Seto, E; Lin, H, 2019, Proceedings of the National Academy of Sciences of the United States of America , Volume: 116, Number: 12, Pages: 5487-5492

Thymic regulatory T cells arise via two distinct developmental programs., Owen, D; Mahmud, S; Sjaastad, L; Williams, J; Spanier, J; Simeonov, D; Ruscher, R; Huang, Weishan; Proekt, I; Miller, C; Hekim, C; Jeschke, J; Aggarwal, P; Broeckel, U; LaRue, R; Henzler, C; Alegre, M; Anderson, M; August, A; Marson, A; Zheng, Y; Williams, C; Farrar, M, 2019, Nature immunology , Volume: 20, Number: 2, Pages: 195-205

Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages., Huang, Weishan; Solouki, S; Carter, C; Zheng, S; August, A, 2018, Frontiers in immunology , Volume: 9, Pages: 2625

ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells., Huang, Weishan; Solouki, S; Koylass, N; Zheng, S; August, A, 2017, Nature communications , Volume: 8, Pages: 15871

 

Grant Funding

Modulation of TCR signaling for sustainable CAR-T therapy, NIH/NIGMS: LSU Center for Pre-Clinical Cancer Research, Principal Investigator, 06/2022-02/2023

Signaling regulation of immune homeostasis , MegaRobo, Principal Investigator, 01/2022-12/2031

Markers and regulation of regulatory CD8+ T cells during influenza-induced lung immunopathology, NIH/NIAID R01, Principal Investigator, 07/2021-06/2026

A rapid and sensitive technology for direct sensing of intact SARS-CoV-2 virions using designer DNA nanostructure probes and a smartphone fluorimeter, NIH/NIBIB R21, Co-Investigator, 09/2021-09/2023 

Regulation of IL10 production in CD8+ T cells during flu infection by tyrosine kinase ITK, NIH/NIAID R01, Co-Investigator, 06/2018-05/2023

Detection and Automatic Privacy-Protected Contact Tracing System Designed for COVID-19, NIH/NIAAA U01, Co-Investigator, 12/2020-11/2022

ITK signaling in tissue resident memory T cell development and function in flu-associated pulmonary sequelae, AAI Careers in Immunology Fellowship, Principal Investigator, 09/2021-08/2022

Heterogeneity and molecular signatures of therapeutic T cells in allergic airway inflammation, NIH/NIAID R56, Principal Investigator, 12/2019-11/2021

Project 2: TCR signaling in IL-10 production by CD8+ T cells during influenza-induced lung immunopathology, NIH/NIGMS P20: LSU-Center for Lung Biology and Disease, Principal Investigator, 01/2019-08/2021, $770,778.00

GCN2 signaling in pathogenic and regulatory T cell development in allergic airway inflammation, NIH/NIAID R21, Principal Investigator, 06/2018-05/2021, $407,000.00

A novel murine model of allergic airway inflammation, NIH/NIAID R21, Co-Principal Investigator, 06/2018-05/2020, $443,292.00

Itk signaling and Type 1 regulatory T cell differentiation and function in allergic airway inflammation, NIH/NIAID R21, Co-Principal Investigator, 12/2017-11/2019, $431,021.00

ITK signaling in type 2 innate lymphoid cell-mediated pulmonary inflammation and fibrosis, LSU-SVM, Competitive Research Program (CORP), Principal Investigator, 06/2018-01/2019, $9,200.00

T cell signals in immune balance and host survival during T. gondii infection, NIH/NIGMS: LSU-Tulane Center for Experimental Infectious Disease and Research, Principal Investigator, 05/2018-01/2019, $50,000.00