PhD, University of Mississippi Medical Center, 2015
MS, University of Mississippi, 2012
MS, University of Southern Mississippi, 2010
BS, University of Southern Mississippi, 2008
My research focuses on evaluating the cardiovascular and pulmonary effects of environmentally persistent free radicals, or EPFRs, using both in vivoand in vitroexposures. In vivostudies are performed using mice and exposing them to the EPFR DCB230 for various lengths of time. After exposures, the mice are evaluated for cardiovascular and lung function and these results are compared to mice which were exposed to filtered air only. The in vitrostudies are carried out using bronchial epithelial cells exposed to the EPFR MCP230. After the cells are exposed to the particles, markers of oxidative stress are measured and compared to non-exposed cells. The overall goal of my studies is to determine the cardiovascular and pulmonary health effects that result from exposure to EPFRs in order to help establish better protocols and improve public health.
Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function. Am J Physiol Heart Circ Physiol, 2021.Ashlyn C. Harmon, A. Noel, B. Subramanian, Z. Perveen, M. H. Jennings, Y. F. Chen, A. Penn, K. Legendre, D. B. Paulsen, K. J. Varner and T. R. Dugas https://pubmed.ncbi.nlm.nih.gov/34415187/
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention. Pharmacol Thera, 2021. Ankit Aryal, A.C. Harmon and T.R. Dugas. https://pubmed.ncbi.nlm.nih.gov/33992684/
Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells. PLoS One, 2018.Ashlyn C. Harmon, V. Y. Hebert, S.C. Cormier, B. Subramanian, J. R. Reed, W. L. Backes, and T.R. Dugas https://pubmed.ncbi.nlm.nih.gov/30308017/