Assistant professor in CBS publishes work highlighting interactions between indoor air pollution and pediatric lung diseases

Superimposition of indoor air pollution onto pediatric genetic disease reveals essential pathway of pathogenicity.



A recent publication from Dr. Yogesh Saini’s laboratory, in the Comparative Biomedical Sciences (CBS) department at the LSU School of Veterinary Medicine, highlights interactions between indoor air pollution and developmental history of pediatric lung diseases such as cystic fibrosis (CF).


The article entitled "Early Postnatal Secondhand Smoke (SHS) Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-obstructive Lung Disease" has been published in the Journal of Immunology


The article is also being featured “In This Issue" section of The Journal of Immunology. "In This Issue" highlights articles considered to be among the top10% of articles published in the journal.


Yogesh Saini, BVSc, MS, PhD, assistant professor in CBS and senior author, says, "This study, first of its kind, reveals the effect of indoor air pollution on imminent pediatric lung diseases. This field of research has immense significance as young children spend 85–90% of their time indoors. Our study has revealed previously underappreciated multidimensional interactions between indoor air pollution, early postnatal lung development, and pathogenesis of obstructive lung disease”.


Brandon Lewis, first author on the manuscript and a graduate student in Dr. Saini’s laboratory, says, “This study reported some of the key effects of SHS exposure and offered comparative novel insight into the interaction of environmental pollutants and muco-obstructive lung diseases. This work has laid the foundation for further research into a scantly researched, but critical area of investigation. Publishing this high impact manuscript will serve as a springboard for my later success as a lung disease researcher, particularly concerning the impact of environmental inhalants on the prognosis of patients afflicted with muco-obstructive lung diseases such as cystic fibrosis”.

Brandon Lewis


Their findings provide a compelling rationale for stronger legislation supporting a ban on cigarette smoking in motor vehicles and homes with young children.


This project was a collaborative effort that incorporated many people within the School of Veterinary Medicine and illustrates the capabilities of the various facilities located within the institution.


This study was funded by the Flight Attendant Medical Research Institute, COBRE Pilot Project and the LSU Faculty Start-Up Package.


Pictured: Top, Dr. Yogesh Saini; Bottom, Brandon Lewis.


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