LSU School of Veterinary Medicine researchers receive $235,000 grant

Funding supports research to treat dogs with elbow osteoarthritis as part of a multi-center clinical trial





BATON ROUGE- Karanvir Singh Aulakh, BVSc & AH, MS, MS, DACVS-SA, assistant professor in Veterinary Clinical Sciences (VCS), is the principal investigator of the research grant, which is funded by Convetra, Inc., a subsidiary of R-NAV, LLC. Lorrie Gaschen, DVM, PhD,, DECVDI, associate dean for Diversity and Faculty Affairs and professor in VCS; Mandi J. Lopez, DVM, MS, PhD, DACVS, professor in VCS; and Frank Andrews, DVM, MS, DACVIM-LA, professor in VCS, are co-principal Investigators of the clinical study. The grant period is for two years, beginning in March 2016.


The study is entitled, “Safety and Efficacy of 117m Sn Colloid for Treatment of Canine Osteoarthritis.” Osteoarthritis is a common disease that causes chronic pain and ambulatory difficulty in humans, dogs and other animals. Commonly-used nonsteroidal and steroid pharmacologic agents can reduce osteoarthritis pain, but extended use may damage other organs such as the liver and kidneys without retarding progression of the disease. The concept behind this new type of treatment is that an intra-articular injection of 117m Sn colloid would localize the treatment to the joint, which would prevent injury to other organs in the body. Since this agent is designed to act on the cellular inflammatory mediators present in the joint, deleterious effects on the joint cartilage and other supporting structures could also be avoided.


Requirements for Dogs entering the 117mSn radiation synoviorthesis trial. 

  • Dogs must be at least 1 year of age
  • Dogs must weigh at least 30lbs
  • Dogs must not have any comorbid condition likely to preclude a one year survival after treatment
  • Dogs must have documentable lameness locatable to one or both elbows
    • Swollen elbow with evidence of lameness and pain on manipulation; or
    • Radiographic evidence of grade one or two arthritis in the elbow. None in shoulder or carpus; or
      • Positive response to regional or intra-articular block of elbow; and
  • No clinical or radiographic evidence of bone neoplasia
  • Dogs must not have evidence of clinical lameness associated with the shoulder or carpus
  • Dogs may be on NSAIDs but must still be lame. Withdrawal of NSAIDS after positive treatment response may be requested by investigators 
  • Owner willing to participate in study by bringing dog to VTH for reassessment at the specified times
  • Owner informed of the need for repeated imaging studies under anesthesia
  • Owner must be willing to keep a daily lameness and medication log
  • Owner understands and signs a consent to participate form
  • Owner understands that the study will not pay for veterinary fees not related to the study


To find out more about the study and for screening your dog for suitability for enrollment in the clinical trial, contact Whitney Soma at


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