Henrique Cheng

Henrique Cheng

Associate Professor

Department of Comparative Biomedical Sciences

LSU School of Veterinary Medicine
Louisiana State University
Baton Rouge, LA 70803

EMAIL DR. CHENG

Education

PhD, Iowa State University

MS, Iowa State University

DVM, Faculdade de Ciencias Agrarias do Para (Brazil)

Research Interest

Our research is focused on the molecular mechanisms controlling stem cell differentiation and pancreatic islet hormone secretion. Another area of interest is spermcellactivation and motility. For these studies,we utilize electrophysiologyandreal-time fluorescence imaging analysis in combination with molecular biology to understand the role of ion channels and intracellular calcium signaling in physiological processes and diseases.

Teaching Interest

My main areas of teaching expertise are physiology, stem cell biology and signal transduction. My primary teaching involves first year veterinary students, but I also teach in the certificate and graduate programs. 

Clinical Interest

Diabetes mellitus, tissue regenerationand infertility.

Awards & Honors

2021 LSU Discover Symposium Award (Hannah Guidry, Undergraduate student)

2021 SVM Dean's Teacher Merit Honor Roll

2020 LSU Discover Symposium Award (Hannah Guidry, Undergraduate student)

2020 SVM Dean's Teacher Merit Honor Roll

2019 SVM Dean's Teacher Merit Honor Roll

2018 SVM Dean's Teacher Merit Honor Roll

2017 SVM Dean's Teacher Merit Honor Roll

2016 Phi Zeta Research Day Award (Tanyawan Suantawee, PhD student)

2016 SVM Dean's Teacher Merit Honor Roll

2016 LSU Dissertation Award (Tran DN Tran, PhD student)

2015 Phi Zeta Research Day Award (Kelsie Stovall, DVM student)

2015 SVM Dean's Teacher Merit Honor Roll

2014 Heidi Lott Dissertation Fellowship Award (Tran DN Tran, PhD student)

2014 SVM Dean's Teacher Merit Honor Roll

2013 Phi Zeta Research Day Award (Amanda Cathey, DVM student)

2013 SVM Dean's Teacher Merit Honor Roll

2012 SVM Dean's Teacher Merit Honor Roll

2011 SVM Dean's Teacher Merit Honor Roll

2011 Best M.S. Thesis Award (Piper Nelson, MS student)

2009 Phi Zeta Research Day Award (Piper Nelson, MS student) 

Publications

Kongthitilerd, P., Thilavech, T., Marnpae, M., Rong, W., Yao, S., Adisakwattana, S., Cheng, H., and Sauntawee, T. (2022). Cyanidin-3-rutinoside stimulated insulin secretion through activation of L-type voltage-dependent Ca2+ channels and the PLC-IP3 pathway in pancreatic β-cells. Biomed. Pharmacother. 146:112494. https://doi.org/10.1016/j.biopha.2021.112494

Cheng, S., Matuguma, S.E., Oliveira, G.H.P., Silva, G.L.R., Cheng, H., Sanchez-Luna, S.A. and Minata, M.K. (2021). Colonoscopic ultrasound (C-US)-guided fine needle aspiration (FNA) using a curvilinear array transducer: A single-center retrospective cohort study. Dis. Colon Rectum. Nov 22. doi: 10.1097/DCR.0000000000002333. PMID: 34840298

Kongthitilerd, P., Sharma, A., Guidry, H.E., Rong, W., Nguyen, J., Yao, S., Adisakwattana, S. and Cheng, H. (2021). Antidiuretic hormone inhibits osteogenic differentiation of dental follicle stem cells via V1a receptors and the PLC-IP3 pathway. Arch. Oral Biol.128:105169. doi: 10.1016/j.archoralbio.2021.105169. PMID: 34058720

Kongthitilerd, P., Suantawee, T., Cheng, H., Thilavech, T., Marnpae, M. and Adisakwattana, S. (2020). Anthocyanin-enriched riceberry rice extract inhibits cell proliferation and adipogenesis in 3T3-L1 preadipocytes by downregulating adipogenic transcription factors and their targeting genes. Nutrients 12(8):2480. doi: 10.3390/nu12082480. PMID: 32824545

Suantawee, T., Thilavech, T., Cheng, H. and Adisakwattana, S (2020). Cyanidin attenuates methylglyoxal-induced oxidative stress and apoptosis in INS-1 pancreatic β-cells by increasing glyoxalase-1 activity. Nutrients 12(5):E1319. doi: 10.3390/nu12051319. PMID: 32384625

Stovall, K.E., Tran, T.D.N., Suantawee, T., Yao, S., Gimble, J.M., Adisakwattana, S. and Cheng H. (2019). Adenosine triphosphate enhances osteoblast differentiation of rat dental pulp stem cells via the PLC-IP3 pathway and intracellular Ca2+ signaling. J. Cell Physiol. doi: 10.1002/jcp.29091. PMID: 31301074

Liu, Y., Cheng, H. and Tiersch, T.R. (2018). The role of alkalinization-induced Ca2+ influx in sperm motility activation of a viviparous fish Redtail Splitfin (Xenotoca eiseni). Biol. Reprod. Dec 1;99(6):1159-1170. PMID: 29982498

Ngoc Tran T.D., Stovall K.E., Suantawee T., Hu Y., Yao S., Yang L.J., Adisakwattana S. and Cheng H. (2017). Transient receptor potential melastatin 4 channel is required for rat dental pulp stem cell proliferation and survival. Cell Prolif. 50(5):e12360. doi: 10.1111/cpr.12360. PMID: 28758259

Suantawee T., Elazab S.T., Hsu W.H., Yao S., Cheng H. and Adisakwattana S. (2017). Cyanidin stimulates insulin secretion and pancreatic β-cell gene expression through activation of L-type voltage-dependent Ca2+ channels. Nutrients 9(8):814. doi: 10.3390/nu9080814. PMID: 28788070

Sompong, W., Cheng, H. and Adisakwattana, S. (2017). Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells. J. Physiol. Biochem. 73(1):121-131. PMID: 27822918

Grants

ACRES Grant Award (PI) 
Title: “Molecular fingerprinting of sperm cells for support of conservation efforts of imperiled live-bearing fishes” 07/2019-06/2021

Dutsadi Phiphat Grant Award, Thailand (PI) 
Title: “Mechanisms of anthocyanin-enrich Riceberry rice extract (Oryza sativa L.) on the regulation of nutrient metabolism and adipogenesis” 10/2019-03/2021

LSU-SVM CORP (PI) 
Title: “Bidirectional regulation of glucagon secretion by GLP-1 in diabetes” 07/2019-06/2020

CBS Bridging Award (PI) 
Title: “Development of a methodology for intracellular Ca2+ recording in sperm bundles from Xiphophorus helleri” 08/2018-07/2019

LSU-SVM CORP (Co-PI; Feng PI) 
Title: “The role of golli protein in insulin secretion of pancreatic beta cells” 07/2017-06/2018

Royal Golden Jubilee Thai Research Foundation, Thailand (PI) 
Title: “Molecular mechanism of anthocyanins in pancreatic β-cells” 10/2015-06/2017