My laboratory seeks to reveal Nature’s molecular blueprint for sustainable solar-to-chemical energy transduction, and to regulate and improve the efficiency of photosynthesis. By combining techniques from molecular biology, protein biochemistry, spectroscopy, and instrument design, we aim to elucidate the mechanisms used by cyanobacteria, algae, and plants to generate O2 from water and sunlight.
Full publication list available at https://scholar.google.com/citations?user=oRRkObMAAAAJ&hl=en&oi=ao
David J. Vinyard and Gary W. Brudvig. “Progress toward a molecular mechanism of water oxidation in Photosystem II.” Annual Review of Physical Chemistry, 2017, 68.
David J. Vinyard, Sahr Khan, Mikhail Askerka, Victor S. Batista, and Gary W. Brudvig. “Energetics of the S2 state spin isomers of the oxygen-evolving complex of Photosystem II.” Journal of Physical Chemistry B, 2017, 121, 1020-1025.
Yuchen Liu, David J. Vinyard, Megan E. Reesbeck, Tateki Suzuki, Kasidet Manakongtreecheep, Patrick L. Holland, Gary W. Brudvig, and Dieter Söll. “A [3Fe-4S] cluster is required for tRNA thiolation in archaea and eukaryotes.” Proceedings of the National Academy of Sciences, USA, 2016, 113, 12703-12708.
David J. Vinyard, Mikhail Askerka, Richard J. Debus, Victor S. Batista, and Gary W. Brudvig. “Ammonia binding in the second coordination sphere of the oxygen-evolving complex of Photosystem II.” Biochemistry, 2016, 55, 4432-4436.
David J. Vinyard, Sahr Khan, and Gary W. Brudvig. “Photosynthetic water oxidation: Binding and activation of substrate waters for O-O bond formation.” Faraday Discussions, 2015, 185, 37-50.
Mikhail Askerka, David J. Vinyard, Gary W. Brudvig, and Victor S. Batista. “Ammonia binding to the S2 state of the oxygen-evolving complex of Photosystem II: Analog to water binding during the S2 → S3 transition.” Biochemistry, 2015, 54, 5783-5786.
David J. Vinyard and Gary W. Brudvig. “Insights into substrate binding to the oxygen-evolving complex of Photosystem II from ammonia inhibition studies.” Biochemistry, 2015, 54, 622-628.
David J. Vinyard, Javier Gimpel, Gennady M. Ananyev, Stephen P. Mayfield, and G. Charles Dismukes. “Engineered Photosystem II reaction centers optimize photochemistry versus photoprotection at different solar intensities.” Journal of the American Chemical Society, 2014, 136, 4048-4055.
David J. Vinyard, Gennady M. Ananyev, and G. Charles Dismukes. “Photosystem II: The reaction center of oxygenic photosynthesis.” Annual Review of Biochemistry, 2013, 82, 577-606.
David J. Vinyard, Javier Gimpel, Gennady M. Ananyev, Mario A. Cornejo, Susan S. Golden, Stephen P. Mayfield, and G. Charles Dismukes. “Natural variants of Photosystem II subunit D1 tune photochemical fitness to solar intensity.” Journal of Biological Chemistry, 2013, 288, 5451-5462.
David J. Vinyard, Chase E. Zachary, Gennady M. Ananyev, and G. Charles Dismukes. “Thermodynamically accurate modeling of the catalytic cycle of photosynthetic oxygen evolution: a mathematical solution to asymmetric Markov chains.” Biochimica et Biophysica Acta – Bioenergetics, 2013, 1827, 861-868.