Dr. Stephania Cormier
Wiener Chair Professor
Honors BS - Biology and Chemistry, 1991
University of Louisiana
PhD - Biochemistry and Molecular Biology, 1997
Louisiana State University Medical Center
Fellowship: Pulmonary and Critical Care Medicine
Mayo Clinic Scottsdale, AZ
Office Phone: 225-578-9437 (ORED) / 225-763-2691 (PBRC)
Lab Phone: 225-578-9762 (PBRC)
Office: L1016 PBRC / ORED 130 D. Boyd
Area of Interest
Respiratory Immunology & Toxicology
The main goal of my laboratory is to determine if exposure during early life to environmental factors (i.e. allergens, pollutants, and respiratory viruses) leads to predisposition, development of, or exacerbation of respiratory disease in the adult. We believe that adult respiratory diseases result, in part, from environmental impacts that occur during a critical phase of immuno-maturation. In the short term, we seek: (1) to define the cellular and molecular changes in the pulmonary microenvironment following gestational and/or neonatal exposure; (2) to determine if urban pollutants (e.g. particulates such as diesel exhaust particles), initiate cellular/molecular events in the developing lung which lead to increased susceptibility to airways disease later in life; (3) to define the impact of respiratory viral infection on pulmonary pathophysiology of the infant; and (4) to understand how urban pollutants impact host defense resulting in enhanced morbidity and increased mortality from respiratory infections.
The long-term objective of my laboratory is to realize the initiators of the immune and pathophysiological changes that occur during the early stages of pulmonary airways disease and ultimately to develop effective interventions and therapies.
Spatiotemporal patterns of childhood asthma hospitalization and utilization in Memphis Metropolitan Area from 2005 to 2015.Oyana TJ, Podila P, Wesley JM, Lomnicki S, Cormier S.The Journal of asthma : official journal of the Association for the Care of Asthma. 2017; 54(8):842-855.
A Scalable Field Study Protocol and Rationale for Passive Ambient Air Sampling: A
Spatial Phytosampling for Leaf Data Collection. Oyana TJ, Lomnicki SM, Guo C, Cormier
SA. Environmental science & technology. 2017; 51(18):10663-10673. NIHMSID: NIHMS934150
IL-4Rα on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. Shrestha B, You D, Saravia J, Siefker DT, Jaligama S, Lee GI, Sallam AA, Harding JN, Cormier SA. Journal of leukocyte biology. 2017; 102(1):153-161.
Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter. Jaligama S, Saravia J, You D, Yadav N, Lee GI, Shrestha B, Cormier SA. Respiratory research. 2017; 18(1):15.
ition 5 5.
A Neonatal Murine Model of MRSA Pneumonia. Fitzpatrick EA, You D, Shrestha B, Siefker
D, Patel VS, Yadav N, Jaligama S, Cormier SA.
Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals. Dugas TR, Lomnicki S, Cormier SA, Dellinger B, Reams M. International journal of environmental research and public health. 2016; 13(6).
Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in adult mice. Stephenson EJ, Ragauskas A, Jaligama S, Redd JR, Parvathareddy J, Peloquin MJ, Saravia J, Han JC, Cormier SA, Bridges D. American journal of physiology. Endocrinology and metabolism. 2016; 310(11):E1003-15.
14th congress of combustion by-products and their health effects-origin, fate, and health effects of combustion-related air pollutants in the coming era of bio-based energy sources. Weidemann E, Andersson PL, Bidleman T, Boman C, Carlin DJ, Collina E, Cormier SA, Gouveia-Figueira SC, Gullett BK, Johansson C, Lucas D, Lundin L, Lundstedt S, Marklund S, Nording ML, Ortuño N, Sallam AA, Schmidt FM, Jansson S. Environmental science and pollution research international. 2016; 23(8):8141-59.
Plasma Biomarker Analysis in Pediatric ARDS: Generating Future Framework from a Pilot Randomized Control Trial of Methylprednisolone: A Framework for Identifying Plasma Biomarkers Related to Clinical Outcomes in Pediatric ARDS. Kimura D, Saravia J, Rovnaghi CR, Meduri GU, Schwingshackl A, Cormier SA, Anand KJ. Frontiers in pediatrics. 2016; 4:31.
Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium. Chen ZH, Wu YF, Wang PL, Wu YP, Li ZY, Zhao Y, Zhou JS, Zhu C, Cao C, Mao YY, Xu F, Wang BB, Cormier SA, Ying SM, Li W, Shen HH. Autophagy. 2016; 12(2):297-311.
Regulation of inflammatory biomarkers by intravenous methylprednisolone in pediatric
ARDS patients: Results from a double-blind, placebo-controlled randomized pilot trial.
Schwingshackl A, Kimura D, Rovnaghi CR, Saravia JS, Cormier SA, Teng B, West AN, Meduri
UG, Anand KJ. Cytokine. 2016; 77:63-71. NIHMSID: NIHMS735976
Using an External Exposome Framework to Examine Pregnancy-Related Morbidities and Mortalities: Implications for Health Disparities Research. Oyana TJ, Matthews-Juarez P, Cormier SA, Xu X, Juarez PD. International journal of environmental research and public health. 2015; 13(1):ijerph13010013.
Corticosteroids in pediatric ARDS: all cards on the table. Schwingshackl A, Meduri GU, Kimura D, Cormier SA, Anand KJ. Intensive care medicine. 2015; 41(11):2036-7. NIHMSID: NIHMS722381
Crawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants. You D, Saravia J, Siefker D, Shrestha B, Cormier SA. Journal of virology. 2015; 90(1):2-4.
Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33. Saravia J, You D, Shrestha B, Jaligama S, Siefker D, Lee GI, Harding JN, Jones TL, Rovnaghi C, Bagga B, DeVincenzo JP, Cormier SA. PLoS pathogens. 2015; 11(10):e1005217.
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