Doerrler lab discovers protein required for resistance to last resort antibiotic colistin

 LSU Graduate student Pradip Panta and Associate Professor William Doerrler confer in the lab LSU Graduate student Pradip Panta and Associate Professor William Doerrler confer in the lab

The Doerrler laboratory has identified a protein called DbcA required for resistance of the Gram-negative bacterium Burkholderia thailandensis to the antibiotic colistin. Related species of Burkholderia cause diseases in both humans (melioidosis caused by B. pseudomallei and opportunistic infections caused by B. cenocepacia) and plants (bacterial panicle blight in rice caused by B. glumae). All Burkholderia species are highly resistant to polymyxin family antibiotics including colistin which is a last resort antibiotic used for the treatment of infections caused by multidrug resistant bacteria. The B. thailandensis protein DbcA belongs to the DedA membrane protein family that the Doerrler lab has previously shown to be required for antibiotic resistance, alkaline tolerance and cell division in Escherichia coli.

Pradip R. Panta, a graduate student in the Department of Biological Sciences, is lead author of the study. Former LSU graduate student Sujeet Kumar and undergraduate students Caroline F. Stafford and Caitlin E. Billiot contributed and are co-authors of the study published recently in Frontiers in Microbiology.

Read the article in Frontiers in Microbiology

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