Oxidative stress (OS) is involved in respiratory disease due to exposure to environmental air pollution. This letter to the editor proposes that a recently recognized by-product of thermal and combustion processes that is capable of inducing OS, and known as environmentally persistent free radicals (EPFRs), is the missing link between exposure and respiratory disease. Dust samples from the homes of 74 children were collected and analyzed for EPFRs. Elevated levels of EPFRs in household dust were found to be strongly associated with persistent and current wheeze. This study was performed in collaboration with Peter Sly, MBBS, MD FRACP, DSc and Keith Grimwood, MD, of The University of Queensland and Griffith University, Qld, Australia; respectively and Slawo Lomnicki, PhD, LSU School of Coast and Environment.
Cormier Lab Published Papers in PubMed June 2019
Elevated Levels of Type 2 Respiratory Innate Lymphoid Cells in Human Infants with Severe RSV Bronchiolitis.
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection and severe bronchiolitis in infants and is responsible for more infant deaths than influenza. The reason that infants are more susceptible to severe RSV infection and severe disease remains unclear. This study utilized nasal aspirates collected with 24 hours of enrollment and developed a novel, feasible methodology for characterizing cellular and humoral components at the mucosal surface - the site of infection. This study for the first time revealed elevated levels of an innate lymphoid cell population (ILC2) and their associated cytokines in the respiratory tract of infants with severe RSV infection. Interestingly, the amount of virus did not affect disease severity. These findings provide not only a new insight about the local innate immune response to RSV but also demonstrate that ILC2 effector cytokines, specifically IL4, can predict probability to develop severe disease within 24 hours of enrollment. This study was performed with the support of families from Le Bonheur Children's Hospital in Memphis and in collaboration with John DeVincenzo, MD, and Tamekia Jones, PhD, University of Tennessee Health Sciences Center, Pediatrics, Memphis, Tennessee.
This manuscript explored the role of lifetime maternal stress to infant bronchiolitis. Over 600 women were questioned and infants followed in this study. The median count (interquartile range) of lifetime traumatic events in these women was 3. While the risk risk of infant bronchiolitis did not increase with the number of traumatice events reported, it did increase with the number of event types reported. Infants born to women reporting multiple types of childhood trauma were at higher risk for bronchiolitis. This work suggests intergenerational effects of traumatic experiences and highlights the need for further research in this area. Kecia Carroll, MD, Margaret Adgent, PhD, and Tebeb Gebretsadik, MPH all of Vanderbilt University School of Medicine, Nashville, Tennessee let this work, which was done in collaboration with me; Frances A. Tylavsky, PhD, and Mehmet Kocak, PhD, of University of Tennessee Health Sciences Center, Memphis, Tennessee; and Omar Elsayed‐Ali, MD, of Emory University School of Medicine, Atlanta, GA; and Rosalind J. Wright, MD, of Icahn School of Medicine at Mount Sinai, New York.