#LouisianaInnovation Fact Sheet

11/11/2014 04:17 PM

LSU is a worldwide leader of innovation, whose researchers discover and develop new advances across multiple fields every day. In recognition of Louisiana’s Innovation Month, #LouisianaInnovation, the following is a fact sheet highlighting LSU’s latest innovative advances.

Louisiana Business and Technology Center
The LBTC Incubator has assisted Louisiana entrepreneurs and small businesses in attracting more than $177 million in loans, equity investments and Small Business Innovation Research or SBIR grants. It has helped create more than 10,000 jobs. Within the past year, it helped nine new businesses launch and raised over $5.2 million in loans, equity and grants. Since the opening of the new prototyping center, ProtoStripes, in August, it has assisted inventors in developing 32 new prototypes.


LSU Student Incubator
Since 2010, the LSU Student Incubator has assisted 122 businesses, raised over $2.8 million in capital and created 78 new jobs. It is currently assisting 31 student businesses.


Pennington Biomedical Research Center
Pennington Biomedical researchers are leaders in cutting edge research on obesity. They discovered a hormone that links obesity with inflammation in fat tissue leading to the tie between excess fat and the development of diabetes, which is key in the fight against diabetes. They recently discovered a new pathway that controls how our bodies respond to a diet that is low in protein, which could improve treatments for obesity and diabetes. They have found links between seemingly unrelated diseases like dementia, Alzheimer’s disease, obesity and cancer. They helped develop Dietary Approaches to Stop Hypertension or the DASH Diet, which has been ranked by U.S. News & World Report as the best diet in America for the 4th year in a row. And they have been involved in the development of all approved obesity medications on the market today, as well as key diabetes medications.

Additionally, Pennington Biomedical Research Center is the primary provider of nutritional research for the U.S. Military and is working to improve the health preparedness of our soldiers. Pennington Biomedical researchers also designed the first of its kind infant whole-body calorimeter that sheds light on a baby’s metabolism and how it plays a role in life long health. Through the Botanical Research Center, Pennington Biomedical scientists are also actively researching Louisiana’s native plants for potential medicinal uses.

For more information, visit www.pbrc.edu or contact Alisha Prather, Communications Director, Pennington Biomedical Research Center at (225) 763-2978 or alisha.prather@pbrc.edu.


Innovation Grants
To increase the number of LSU innovations licensed to industry partners, the LSU Board of Supervisors and President and Chancellor F. King Alexander announced the Leveraging Innovation for Technology Transfer, or LIFT2, fund. It will grant $500,000 to fund 15 innovations, which will include creative and artistic works as well as devices, drugs, software and other more traditional concepts. It is currently receiving Requests for Proposals through Dec. 15. Awards will be granted on Jan. 31, 2015.
For more information, visit: https://sites01.lsu.edu/wp/ored/files/2014/11/RFP-for-LIFT-Pilot-Round-2-Final-10.30.14.pdf


In addition, the Research Park Corporation approved $250,000 to launch the LSU Re-LIFT2 program, in partnership with the LSU Research and Technology Foundation. Re-LIFT compliments LSU’s LIFT2 Fund, which funds research projects across the LSU System which have yet to be licensed, optioned or otherwise committed to a commercial partner.


Newly Issued LSU Patents
Electrical Resonance Detection of Particles and Analytes

US Patents 8,587,330 and 8,390,304
Inventor: Donald A. Patterson

This practical, inexpensive and very sensitive conductivity-based counter provides high speed, accurate counting of discrete analytes, such as protein or peptide fragments, or other objects, such as cancer cells, as they pass through a fluid sample cell. The device is not limited to aqueous solutions. It offers a number of significant advantages. For example, while Coulter counters can be very fast, our novel equivalent RLC circuitry’s minimization of stray capacitance (which must be estimated for each sample cell geometry in bipolar pulse methods) vastly improves sensitivity, resulting in a substantially less complex, faster, more accurate and easy-to-use instrument.


Oncolytic Herpes Virus Type-1 for the Treatment of Cancers
US Patent 8,586,028
Inventor: Gus Kousoulas

Oncolytic HSV has shown to have significant promise for the treatment of many different types of tumors in preclinical studies in experimental animals as well as in human clinical trials. Tumor treatment with oncolytic HSV has been shown to induce antitumor immune responses. This invention is a new oncolytic herpes simplex virus type-1 that was engineered to quickly replicate and spread in cancer cells without spreading to normal cells. The new viruses have specific gene deletions to ensure safety and preferential replication in cancer cells. In addition, these viruses have one or more mutations within viral genes that cause extensive virus-induced cell fusion (syncytial mutations) ensuring efficient spread of the virus within tumors.


Improved Method for Isolating Stem Cells from Adult Tissues
US Patent 8,501,397
Inventors: Gary Wise and Shaomian Yao

Current methods of purifying stem cells heavily rely on marker-dependent cell sorting techniques. The major problem of such technologies is that adult stem cells lack unique, specific and easily detectable markers. Additionally, this sorting process can cause cell damage, resulting in a low recovery rate or loss of stem cell function, and can require expensive equipment. Other purifying methods are based on colony formation properties or unreliable parameters such as cell adherence, size or density. These methods are labor intensive, time consuming or incompatible with large scale purification; or they lack adequate specificity.

This novel process selectively kills or eliminates non-stem cells from a heterogeneous cell population (one with both stem cells and non-stem cells) so that stem cells can be isolated. By subjecting a heterogeneous cell population to appropriate stress, non-stem cells are selectively eliminated thus resulting in the enrichment of stem cells in the population. Researchers have demonstrated that by using this novel process, a greater percentage of the cells remaining after the applied stress are stem cells, based on traditional stem cell markers and on the ability of the cells to differentiate into multiple types of cells. This method will allow purification of stem cells on a large scale without requirement of expensive equipment, and does not require the presence of cell surface markers. Stem cells produced by this method can be used for clinical applications, including tissue engineering.

Developed by the Louisiana Innovation Council in partnership with Louisiana Economic Development, regional and local economic development agencies, and higher education institutions across the state, Louisiana Innovation Month is a celebration of business creativity and innovation for the entire State of Louisiana. Innovation Month provides the opportunity to coordinate efforts among these partners and position them as catalysts for the development of a more diverse knowledge-sector based economy. Follow the hashtag #LouisianaInnovation for more on innovation in the state.

Alison  Satake 
LSU Media Relations

Posted on Tuesday, November 11, 2014