LSU Vet Med researcher receives $550,000 grant to study DNA repair

FOR IMMEDIATE RELEASE: October 17, 2016 

 

Dr. LiBATON ROUGE—Shisheng Li, PhD, professor of Comparative Biomedical Sciences at the LSU School of Veterinary Medicine (LSU SVM), received a $550,000 grant from the National Science Foundation. The project is entitled “The role of Sen1 in transcription coupled DNA repair (TCR)” and runs from July 1, 2016, through June 30, 2019.

 

DNA repair plays a vital role in almost all types of lives. This project addresses the mechanism of how the Sen1 protein is implicated in transcription coupled DNA repair (TCR), a DNA repair subpathway, in the model organism of budding yeast (Saccharomyces cerevisiae). Sen1 is the homolog of human senataxin, a protein implicated in ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). Given the fact that the DNA repair mechanisms are highly conserved, the findings generated from the yeast studies are likely to be applicable to other species, including human.

 

Dr. Li joined the faculty at the LSU SVM in 2004. He received his BS from Henan Normal University (China) in 1985, his MS from Nankai University (China) in 1988 and his PhD from the University of Wales (United Kingdom) in 1997.

 

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