FALL SEMINAR SERIES
Comparative Biomedical Sciences
Room 1212C - School of Veterinary Medicine
Isabelle Miousse, PhD
Department of Environmental and Occupational Health
College of Public Health
University of Arkansas for Medical Sciences
Host: Dr. Alexandra Noël
"New paradigms in radiation, methyl donors, and cancer"
DNA and histone methylation are keystones of epigenetic regulation of gene expression and preservation of genome stability. Both marks are profoundly altered after toxic exposures such as irradiation, and play a role in the development of cancer. The ability of the cell to properly methylate DNA and histone depends on the availability of methyl groups, supplied and recycled through the methionine cycle. Our project explores the many ways in which dietary manipulations of the methyl donor methionine have profound effects on the outcomes of healthy and cancer tissues when exposed to radiation. Lower levels of methionine intake are associated with protection of healthy cells, with a particularly beneficial effect in mitigating bowel radiation injury. Reduced methionine also leads to reduced tumor growth, and inhibition of metastasis. The results of this study may have profound effects in decreasing the short term toxicity of radiotherapy and reducing long term side effects, leading to an increase in life quality for the growing population of cancer survivors.
Thursday, September 28, 2017
9 a.m. *NEW TIME*
Thanks to our Guest Speakers for Fall 2017
Thursday, August 31, 2017
Thank you, Dr. Min Wu!
Professor of Immunology & Microbiology
Department of Biochemistry and Molecular Biology
University of North Dakota
JOURNAL CLUB - FALL 2017
Room 2502 - School of Veterinary Medicine
Tuesday, September 26, 2017
"Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology"
An article by Dr. Isabelle R. Miousse, the CBS guest speaker for September 28, 2017
Presented by Mingyang Li