FALL SEMINAR SERIES                       

Comparative Biomedical Sciences                  

Room 1212C - School of Veterinary Medicine



Jacob Raber, PhD

Professor of Behavioral Neuroscience, Neurology and Radiation Medicine

Oregon Health & Science University



Host: Dr. Arthur Penn


 "High-fat diet, insulin resistance, apoE isoform, and cognitive injury"


The elderly population is expanding rapidly, and by 2050, the percentage of the world population aged 65 years or older will more than double to 1.6 billion individuals. Concurrently, diabetes has reached epidemic proportions worldwide. Projected rates of diabetes over the next two decades are staggering; a 165% increase in the number of patients with diabetes, with the largest increase in individuals over 75 years of age. Type 2 Diabetes (T2D) accounts for over 90% of all diabetes incidence and is characterized by obesity and insulin resistance (IR). The major modifiable risk factor for T2D is obesity while the primary contributors to obesity are sedentary lifestyle and caloric excess, particularly in the form of “Western” style diets high in saturated fat. Obesity, IR, and T2D increase the risk of developing vascular disease, including both atherosclerosis and vascular dementia. Metabolic dysfunction, commonly a result of diets high in saturated fats and sugar, is associated with impaired cognitive function and an increased risk of age-related cognitive decline (ACD) and Alzheimer’s Disease (AD). Compared to the E3 isoform of apolipoprotein (apoE), the E4 isoform is a major genetic risk factor for ACD, AD, and for developing cognitive impairments following various environmental challenges, including dietary challenges such as a high-fat diet (HFD). Both IR and E4 are associated with metabolic and vascular impairments. Deficits in cerebral metabolism and cerebrovascular function have been proposed as initiating events leading to these impairments. We use human apoE targeted replacement mice and HFD-induced obesity to study the potential link between E4 and IR and to test the hypothesis that, compared to E3 mice, E4 mice are more susceptible to the harmful cognitive effects of HFD-induced IR due to apoE isoform-dependent effect in the hippocampus. Data supporting this hypothesis will be presented and discussed.



Thursday, November 16, 2017
12 Noon





Thanks to our Guest Speakers for Fall 2017


Thursday, August 31, 2017

Thank you, Dr. Min Wu!

Professor of Immunology & Microbiology
Department of Biochemistry and Molecular Biology
University of North Dakota


Thursday, September 28, 2017

Thank you, Dr. Isabelle Miousse!

Postdoctoral Fellow
Department of Environmental and Occupational Health
University of Arkansas for Medical Sciences


Thursday, October 12, 2017

Thank you, Dr. Hongju Wu!

Associate Professor
Departments of Medicine and Physiology
Tulane University School of Medicine, New Orleans


Thursday, October 19, 2017

Thank you, Dr. Lung-Chi Chen!

Professor of Environmental Medicine
Department of Environmental Medicine
New York University School of Medicine


Thursday, October 26, 2017

Thank you, Dr. Enid Neptune!

Associate Professor of Medicine
Division of Pulmonary and Critical Care Medicine
Department of Medicine, John Hopkins University





Room 2502 - School of Veterinary Medicine

Tuesday, November 14, 2017

12 Noon


  "Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition

and Alter the Epigenome and Metabolome"


An article from the lab of Dr. Jacob Raber, the CBS guest speaker for November 16, 2017

Presented by Luciana Costa