Jason  D.  Walker 
    Post-doctoral Researcher
    Bachelor's Degree(s): Louisiana State University, 1996
    Master's Degree: MPhil, Yale University, 2006
    PhD: Yale University, 2008
    Phone: 225-578-9619
    jdwalk@lsu.edu
    Office: VMED 3104

     

    Area of Interest
     

    My current research interests involve the design and construction of novel cancer therapies using human herpes simplex virus as a vector to treat solid tumors. These studies take advantage of my experience in genetics, virology, and immunology. I have produced several novel viruses that are intended to shrink tumors directly through lytic replication and indirectly through immune activation using immunomodulatory transgenes. I believe that engaging the immune system in controlling tumor metastasis and growth will be key to the elimination of refractory cancers.

     

    Positions held

    1996-2002 Research Associate, Louisiana State University (LSU), Dept of Biological Sciences
    2003-2006 National Science Foundation Graduate Research Fellow, Yale University, Dept of Genetics
    2008-Curr Postdoctoral Researcher, LSU, School of Veterinary Medicine, Dept of Pathobiological Sciences
     
     
    Selected Publications
     

    1.            Chowdhury S, Naderi M, Chouljenko VN, Walker JD, Kousoulas KG. Amino Acid Differences in Glycoproteins B (gB), C (gC), H (gH) and L(gL) are Associated with Enhanced Herpes Simplex Virus type-1 (McKrae) Entry via the Paired Immunoglobulin-like Type-2 Receptor. Virology Journal. 2012;9(1):112. Epub 2012/06/15. doi: 10.1186/1743-422X-9-112. PubMed PMID: 22695228.

     

    2.            Chouljenko DV, Kim IJ, Chouljenko VN, Subramanian R, Walker JD, Kousoulas KG. Functional Hierarchy of Herpes Simplex Virus Type-1 (HSV-1) Viral Glycoproteins in Cytoplasmic Virion Envelopment and Egress. Journal of Virology. 2012. Epub 2012/02/10. doi: 10.1128/JVI.06766-11. PubMed PMID: 22318149.

     

    3.            Walker JD, Sehgal I, Kousoulas KG. Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice. Journal of Virology. 2011;85(14):7363-71. Epub 2011/05/06. doi: 10.1128/JVI.00098-11. PubMed PMID: 21543507; PubMed Central PMCID: PMC3126558.

     

    4.            Kasili R, Huang CC, Walker JD, Simmons LA, Zhou J, Faulk C, et al. BRANCHLESS TRICHOMES links cell shape and cell cycle control in Arabidopsis trichomes. Development. 2011;138(11):2379-88. Epub 2011/05/12. doi: 10.1242/dev.058982. PubMed PMID: 21558384.

     

    5.            Jambunathan N, Chowdhury S, Subramanian R, Chouljenko VN, Walker JD, Kousoulas KG. Site-specific proteolytic cleavage of the amino terminus of herpes simplex virus glycoprotein K on virion particles inhibits virus entry. Journal of Virology. 2011;85(24):12910-8. Epub 2011/10/14. doi: 10.1128/JVI.06268-11. PubMed PMID: 21994443; PubMed Central PMCID: PMC3233161.

     

    6.            Kasili R, Walker JD, Simmons LA, Zhou J, De Veylder L, Larkin JC. SIAMESE cooperates with the CDH1-like protein CCS52A1 to establish endoreplication in Arabidopsis thaliana trichomes. Genetics. 2010;185(1):257-68. Epub 2010/03/03. doi: 10.1534/genetics.109.113274. PubMed PMID: 20194967; PubMed Central PMCID: PMC2870961.

     

    7.            Walker JD, Maier CL, Pober JS. Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes. J Immunol. 2009;182(3):1548-59. Epub 2009/01/22. PubMed PMID: 19155503; PubMed Central PMCID: PMC2630120.

     

    8.            Okuma K, Boritz E, Walker J, Sarkar A, Alexander L, Rose JK. Recombinant vesicular stomatitis viruses encoding simian immunodeficiency virus receptors target infected cells and control infection. Virology. 2006;346(1):86-97. Epub 2005/12/06. doi: 10.1016/j.virol.2005.10.041. PubMed PMID: 16325218.

     

    9.            Churchman ML, Brown ML, Kato N, Kirik V, Hulskamp M, Inze D, et al. SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. The Plant cell. 2006;18(11):3145-57. Epub 2006/11/14. doi: 10.1105/tpc.106.044834. PubMed PMID: 17098811; PubMed Central PMCID: PMC1693949.

     

    10.          Choi J, Walker J, Talbert-Slagle K, Wright P, Pober JS, Alexander L. Endothelial cells promote human immunodeficiency virus replication in nondividing memory T cells via Nef-, Vpr-, and T-cell receptor-dependent activation of NFAT. Journal of Virology. 2005;79(17):11194-204. Epub 2005/08/17. doi: 10.1128/JVI.79.17.11194-11204.2005. PubMed PMID: 16103171; PubMed Central PMCID: PMC1193601.

     

    11.          Choi J, Walker J, Boichuk S, Kirkiles-Smith N, Torpey N, Pober JS, et al. Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo. Journal of Virology. 2005;79(1):264-76. Epub 2004/12/15. doi: 10.1128/JVI.79.1.264-276.2005. PubMed PMID: 15596822; PubMed Central PMCID: PMC538695.

     

    12.          Wolfe AJ, Chang DE, Walker JD, Seitz-Partridge JE, Vidaurri MD, Lange CF, et al. Evidence that acetyl phosphate functions as a global signal during biofilm development. Molecular Microbiology. 2003;48(4):977-88. Epub 2003/05/20. PubMed PMID: 12753190.

     

    13.          Walker JD, Oppenheimer DG, Concienne J, Larkin JC. SIAMESE, a gene controlling the endoreduplication cell cycle in Arabidopsis thaliana trichomes. Development. 2000;127(18):3931-40. Epub 2000/08/23. PubMed PMID: 10952891.

     

    14.          Larkin JC, Walker JD, Bolognesi-Winfield AC, Gray JC, Walker AR. Allele-specific interactions between ttg and gl1 during trichome development in Arabidopsis thaliana. Genetics. 1999;151(4):1591-604. Epub 1999/04/02. PubMed PMID: 10101180; PubMed Central PMCID: PMC1460562.