Wayne L. Backes

Associate Dean for Research and Professor of Pharmacology, Louisiana State University Health Sciences Center-New Orleans

LSU Superfund Research Program leader - Pollutant-Particle Systems and Xenobiotc Bioactivation

 Backes

Contact:

Phone: (504) 568-6557

Fax: (504) 568-6888

Email: wbacke@lsuhsc.edu

Websites: http://www.medschool.lsuhsc.edu/pharmacology/faculty/Backes.htm

http://www.medschool.lsuhsc.edu/pharmacology/faculty_detail.aspx?name=backes_wayne

 

Research interests, expertise:

  • Organization and Complex Formation among Multiple Cytochrome P450 Enzymes in the Endoplasmic Reticulum
  • Interaction of Heme Oxygenase 
  • Cytochrome P450 their Electron Transfer Partners in the Endoplasmic Reticulum 

 

Recent publications:

2015

Reed, J.R., Cruz, A.L., Lomnicki, S.M., Backes, W.L. 2015. Inhibition of Cytochrome P450 2B4 by Environmentally Persistent Free Radical-Containing Particulate Matter. Biochem Pharmacol. 95(2):126-32. Doi: 10.1016/j.bcp.2015.03.012. PMCID:
PMC4406862

 

Reed, J. R., dela Cruz, A. L. N., Lomnicki, S. M., & Backes, W. L. 2015. Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2. Toxicology and Applied Pharmacology. 289(2), 223-230. doi:http://dx.doi.org/10.1016/j.taap.2015.09.021

 

Park, J. W., Reed, J. R., & Backes, W. L. 2015. The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions. Journal of Biological Chemistry. 290(49), 29449-29460. doi:10.1074/jbc.M115.687103

 

2014 

Johnson, E.F., Connick, J.P., Reed, J.R., Backes, W.L., Desai, M.C., Xu, L., Estrada, R., Laurence, J.S., and Scott, E.E. 2014. Correlating Structure and Function of Drug-Metabolizing Enzymes: Progress and Ongoing Challenges. Drug Metabolism and Disposition. 42 (1): 9-22. Doi: 10.1124/dmd.113.054627. PMCID: PMC3876788

 

Reed, J.R., Cawley, G.F., Ardoin, T.G., Dellinger, B., Lomnicki, S.M., Hasan, F., Kiruri, L.W.,  Backes, W.L. 2014. Environmentally Persistent Free Radicals Inhibit Cytochromes P450 Activity in Rat Liver Microsomes. Toxicol Appl Pharmacol. Doi: 10.1016/j.taap.2014.03.021. PMCID:PMC4049543

 

2013

Reed, J.R., Cawley, G.F. and Backes, W.L. 2013. Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncoupling. Biochemistry. 52(23):4003-4013. Doi:10.1021/bi400422a. PMCID: PMC3750074 

 

2012

Reed, J.R. and Backes, W.L. 2012. Formation of P450•P450 Complexes and Their Effect on P450 Function. Pharmacol Ther. 133(3):299-310. Doi: 10.1016/j.pharmthera.2011.11.009. PMCID:PMC3272114.

 

Reed, J.R., Connick, J.P., Cheng, D., Cawley, G.F., and Backes, W.L. 2012. Effect of Homomeric P450•P450 Complexes on P450 Function. Biochem J. 446(3):489-97. Doi: 10.1042/BJ20120636. PMCID:PMC3518449.

 

2011 

Reed, J.R., Cawley, G.F., and Backes, W.L. 2011. Assessing an Antioxidant Role for HO-1 in the Inhibition of P450-Mediated Production of Reactive Oxygen Species in Rat Liver Microsomes. Drug Metabolism Letters. 5, 6-16.

 

Brignac-Huber, L., Reed, J.R., and Backes, W.L. 2011. Organization of NADPH-Cytochrome P450 Reductase and CYP1A2 in the Endoplasmic Reticulum – Microdomain localization affects monooxygenase function. Mol. Pharmacol. 79, 549-557.

 

Marohnic, C.C., Huber, W.J. III, Connick, J.P., Reed, J.R., McCammon, K., Panda, S.P., Martásek, P., Backes, W.L., and Masters, B.S.S. 2011. Mutations of Human Cytochrome P450 Reductase Differentially Modulate Heme Oxygenase-I Activity and Oligomerization. Arch. Biochem. Biophys. (in press).

 

2010

Reed, J.R., Eyer, M., and Backes, W.L.  2010. Functional Interactions between Cytochromes P450 1A2 and 2B4 Require Both Enzymes to Reside in the Same Phospholipid Vesicle: Evidence for physical complex formation. J. Biol. Chem. 285, 8942-8952. 

 

Reed, J.R., Huber, W.J., and Backes, W.L. 2010. Human Heme Oxygenase-1 Efficiently Catabolizes Heme in the Absence of Biliverdin Reductase. Drug Metab. Dispos. 38, 2060-2066.