Area of Interest
My research focuses on understanding the ways plants respond to environmental stress at the molecular and biochemical levels. Current projects include:
1) Identifying how environmental stressors, such as mineral nutrient deficiencies, affect gene regulation via chromatin remodeling.
2) Manipulating the transport of arsenic into and within plants via various genetic engineering strategies for human health and phytoremediation applications.
Fontenot EB, DiTusa SF, Kato N, Olivier DM, Dale R, Lin WY, Chiou TJ, Macnaughtan MA, Smith AP. Increased phosphate transport of Arabidopsis thaliana Pht1;1 by site-directed mutagenesis of tyrosine 312 may be attributed to the disruption of homomeric interactions. Plant Cell &Environ. In press.
Smith AP, Fontenot EB, Zahraeifard S, and DiTusa SF. Molecular components that drive phosphorus-remobilization during leaf senescence. In: Phosphorus metabolism in plants. Plaxton W and Lambers H eds. Wiley Blackwell. In press.
Smith AP (2013) Systemic signaling in the maintenance of phosphate homeostasis. In: Long-distance systemic signaling and communication in plants. Baluška F ed. Springer Berlin Heidelberg, 149-166.
Bovenkamp GL, Prange A, Schumacher W, Ham K, Smith AP, and Hormes J. (2013) Lead uptake in diverse plant families: a study applying X-ray Absorption Near Edge Spectroscopy. Env Sci & Tech. 47, 4375-82.
LeBlanc MS, McKinney EC, Meagher RB, and Smith AP. (2013) Hijacking membrane transporters for arsenic phytoextraction. J of Biotechnol. 163, 1-9.
Nagarajan VK and Smith AP. (2012) Ethylene’s role in phosphate starvation signaling; more than just a root growth regulator. Plant Cell & Physiol. 53, 277-286.
Smith AP, Nagarajan VK, and Raghothama KG. (2011) Arabidopsis Pht1;5 plays an integral role in phosphate homeostasis. Plant Signal Behav. 6, 1676-1678.
Nagarajan VK, Jain A, Poling MD, Lewis AJ, Raghothama KG, and Smith AP. (2011) Arabidopsis Pht1;5 mobilizes phosphate between source and sink organs, and influences the interaction between phosphate homeostasis and ethylene signaling. Plant Physiol. 156, 1149-63.
Smith AP, Jain A, Deal RB, Nagarajan VK, Poling MD, Raghothama KG, and Meagher RB. (2010) Histone H2A.Z regulates the expression of several classes of phosphate starvation response genes, but not as a transcriptional activator. Plant Physiol. 152, 217-225.
Meagher RB, Kandasamy MK, Smith AP, and McKinney EC. (2010) Nuclear actin-related proteins at the core of epigenetic control. Plant Signal Behav. 5, 518-522.
Kandasamy MK, McKinney EC, Deal RB, Smith AP, and Meagher RB. (2009) Arabidopsis actin-related protein ARP5 in multicellular development and DNA repair. Dev Biol. 335, 22-32.
Jain A, Poling MD, Smith AP, Nagarajan VK, Lahner B, Meagher RB, and Raghothama KG. (2009) Variations in the composition of gelling agents affect morphophysiological and molecular responses to deficiencies of phosphate and other nutrients. Plant Physiol. 150, 1033-49.
Li Y, Dankher OP, Carreira L, Smith AP, and Meagher RB. (2006) The shoot-specific expression of gamma-glutamylcysteine synthetase directs the long-distance transport of thiol-peptides to roots conferring tolerance to mercury and arsenic. Plant Physiol. 141, 288-298.