Area of Interest

 The main goal of my laboratory is to determine if exposure during early neonatal life to environmental factors (i.e. allergens, pollutants, and respiratory viruses) leads to predisposition, development of, or exacerbation of respiratory disease in the adult. We believe that adult respiratory diseases result, in part, from environmental impacts that occur during a critical phase of immuno-maturation. In the short term, we seek: (1) to define the cellular and molecular changes in the pulmonary microenvironment following gestational and/or neonatal exposure to allergens; (2) to determine if urban pollutants (e.g. particulates such as diesel exhaust particles), initiate cellular/molecular events in the developing lung which lead to increased susceptibility to airways disease later in life; and (3) to define the impact of respiratory viral infection on pulmonary pathophysiology of neonatal mice. 

The long-term objective of my laboratory is to realize the initiators of the immune and pathophysiological changes that occur during the early stages of pulmonary airways disease and ultimately to develop effective interventions and therapies.  


Selected Publications

 Cormier, SA and Kolls, JK. 2011. Innate IL-13 in viral-induced asthma?  Nature Immunology. 12:587-8.

Wang P, Thevenot P, Saravia J, Ahlert T, and Cormier, SA. 2011. Radical Containing Particles Activate DCs and Enhance Th17 Inflammation in a Mouse Model of Asthma. American Journal of Respiratory Cell and Molecular Biology. 45:977-83. Featured in ATS News: What’s New In AJRCMB.

Lord K, Moll D, Lindsey JK, Mahne S, Raman G, Dugas T, Cormier S, Troxlair D, Lomnicki S, Dellinger B, and Varner K. 2011. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo. Journal of Receptor and Signal Transduction Research 31:157-67.

Balakrishna S, Saravia J, Thevenot P, Ahlert T, Lominiki S, Dellinger B, and Cormier SA. 2011. Environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs. Particle Fibre and Toxicology. 8:11.

You D, Honnegowda S, and Cormier SA. 2010. The Use of Neonatal Mouse Models to Study Respiratory Syncytial Virus Infections. Expert Reviews in Anti-Infect Therapeutics. 8(12), 1371–1380.

Ripple M, You D, Honnegowda S, Giaimo J, Sewell A, Becnel DM, and Cormier SA. Immunomodulation with IL-4RαAntisense Oligonucleotide Prevents Respiratory Syncytial Virus-Mediated Pulmonary Disease. Journal of Immunology. 2010;185:4804-4811. Faculty of 1000 Biology Recommended. Featured on MDLinx and Targeted Intelligence Report. 

Walsh M, Cormier S, Varner K, and Dellinger B. 2010. By-Products of Thermal Treatment of Hazardous Waste—Formation and Health Effects. EM. April:26-30.

Fahmy B, Ding L, You D, Lomnicki S, Dellinger B, and Cormier SA. 2010. In Vitro and In Vivo Assessment of Pulmonary Risk Associated with Exposure to Combustion Generated Fine Particles. Environmental Toxicology and Pharmacology. 29:173–182

Cormier SA, You D, Honnegowda S. 2010. The use of a neonatal mouse model to study respiratory syncytial virus infections. Expert Review of Anti-Infective Therapy. 2010 8:1371-80. 

Fahmy B, Cormier SA. 2009. Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicology In Vitro. 23:1365-71. 

Wang X, Xu W, Kong X, Chen D, Hellermann G, Ahlert TA, Giaimo JD, Cormier SA, Li X, Lockey RF, Mohapatra S, Mohapatra SS. 2009. Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma. Respiratory Research. 2009;10:66.

Balakrishna S, Lomnicki S, McAvey KM, Cole RB, Dellinger B, and Cormier SA. 2009. Environmentally persistent free radicals amplify ultrafine particle mediated cellular oxidative stress and cytotoxicity. Particle Fibre and Toxicology. 6: 11.

You D, Ripple M, Balakrishna S, Troxclair D, Sandquist D, Ding L, Ahlert TA, and Cormier SA. 2008. Inchoate CD8+ T Cell Responses in Neonatal Mice Permit Influenza Induced Persistent Pulmonary Dysfunction. The Journal of Immunology.181: 3486-3494.

Naura AS, Hans CP, Zerfaoui M, You D, Cormier SA, Oumouna M, and Boulares AH. 2008. Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. Clinical & Experimental Allergy 38:839-846.

Wang K, You D, Balakrishna S, Ripple M, Ahlert T, Fahmy B, Becnel D, Daly M, Subra W, McElduff JS, Lomax LG, Troxclair D, and Cormier SA. 2008. Sediment from Hurricane Katrina: Potential to Produce Pulmonary Dysfunction in Mice. International Journal of Clinical and Experimental Medicine 1:130-144.

You D, Becnel D, Wang K, Ripple M, Daly M, and Cormier SA. 2006. Exposure of Neonates to Respiratory Syncytial Virus is Critical in Determining Subsequent Airway Response in Adults. Respiratory Research. 7:107. Highly Accessed.

Cormier SA, Taranova AG, Bedient C, Nguyen T, Protheroe P, Pero R, Dimina D, Lenkiewicz E, Ochkur SI, O'Neill K, Colbert D, Lombari TR, McGarry MP, Lee JJ, and Lee NA. 2006. Eosinophil Infiltration of Solid Tumors Is an Early Host Response That Potentially Modulates Cancer Growth. Journal of Leukocyte Biology. 79: 1131-1139. Faculty of 1000 Biology Recommended.

Cormier SA, Lomnicki S, Backes W, and Dellinger B. 2006. Origin and health impacts of emissions of toxic by-products and fine particles from combustion and thermal treatment of hazardous wastes and materials. Environmental Health Perspectives. 114:810-817.

Becnel D,You D,Erskin J,Dimina DM, and Cormier SA. 2005. A role for airway remodeling during respiratory syncytial virus infection. Respiratory Research 6:122. Highly Accessed.

Lee JJ, Dimina DD, Macias MP, Ochkur SI, McGarry MP, O’Neill KR, Protheroe C, Pero R, Nguyen T, Cormier SA, Lenkiewicz E, Colbert D, Rinaldi L, Ackerman SJ, Irvin CG, and Lee NA. 2004. Mice Congenitally Deficient of Eosinophils Define a Link with Asthma. Science. 305:1773-1776. Faculty of 1000 Biology Must Read.

Hao M, Cormier S, Wang M, Lee JJ, and Nel A. 2003. Diesel Exhaust Particles Exert Acute Effects on Airway Inflammation and Function in Murine Allergen Provocation Models. Journal of Allergy and Clinical Immunology. 1125:905-914.

Borchers MT, Biechele T, Justice P, Ansay T, Cormier S, Mancino V, Wilkie TM, Simon MI, Lee NA and Lee JJ. 2003. Methacholine-induced airway hyperresponsiveness is dependent on Gaq signaling. American Journal of Physiology – LCMP. 285:L114-L120.

Shen H, Ochkur SI, McGarry MP, Crosby JR, Hines E M, Borchers MT, Wang H, Biechele TL, O'Neill KR, Ansay TL, Colbert DC, Cormier SA, Justice JP, Lee JJ, and Lee NA. 2003. A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. Journal of Immunology. 170:3296-3305. Faculty of 1000 Biology Recommended.

Cormier SA, Mello MA, and Kappen C. 2003. Normal proliferation and differentiation of Hoxc-8 transgenic chondrocytes in vitro. BMC Dev Biol 3(1):4.

Cormier S, Yuan S, Crosby J, Dimina D, Protheroe C, Lee NA, and Lee JJ. 2002. TH2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology. 27: 678-687.

Denzler KL, Borchers MT, Crosby JR, Cieslewicz G, Hines EM, Justice JP, Cormier SA, Lindenberger KA, Song W, Wu W, Hazen SL, Gleich GJ, Lee JJ, Lee NA. 2001. Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation. The Journal of Immunology. 167:1672-1682.

Cormier S, Larson KA, Yuan S, Mitchell TL, Lindenberger K, Carrigan P, Lee NA, and Lee JJ. 2001. Mouse eosinophil associated ribonucleases: a unique subfamily expressed during hematopoesis. Mammalian Genome. 12:352-361.

Denzler KL, Farmer SC, Crosby JR, Borchers M, Cieslewicz G, Larson KA, Cormier-Regard S, Lee NA, and Lee JJ. 2000. Eosinophil Major Basic Protein-1 (mMBP-1) does not contribute to allergen-induced airway pathologies in mouse models of asthma. The Journal of Immunology. 165:5509-17.

Cormier-Regard S,Nguyen SV, and Claycomb WC. 1998. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. Journal of Biological Chemistry. 273: 17787-17792. 

Cormier-Regard S, Egeland DB, Tannoch VJ, and Claycomb WC. 1997. Differential display:  identifying genes involved in cardiomyocyte proliferation. Molecular and Cellular Biochemistry. 172: 111-120.

See my publications on PubMed