Zhi-Yuan Chen
Associate Professor

Publications [Published Items Only]

Refereed Journal Articles

Chen, Z. -Y., Brown, R. L., Menkir, A., and Cleveland, T. E. 2012. Identification of resistance-associated proteins in closely-related maize lines varying in aflatoxin accumulation. Molecular Breeding 30: 53-68.

Luo, M., Brown, R. L., Chen, Z. –Y., Menkir, A., Yu, J., and Bhatnagar, D. 2011.  Transcriptional profiles uncover Aspergillus flavus-induced resistance in maize kernels. Toxins 3:766-785.

Cary, J. W., Rajasekaran, K., Brown, R. L., Luo, M., Chen, Z. –Y., and Bhatnagar, D. 2011. Developing resistance to aflatoxin in maize and cottonseed. Toxins 3:678-696.

Chen, Z. -Y., Brown, R. L., Damann, K. E., and Cleveland, T. E. 2010. PR10 expression in maize and its effect on host resistance against Aspergillus flavus infection and aflatoxin production. Molecular Plant Pathology 11:69-81.

Xie, Y., Chen, Z. -Y., Brown, R. L., and Bhatnagar, D. 2010 Expression and functional characterization of two pathogenesis-related protein 10 genes from Zea mays. J. Plant Physiology 167:121-130.

Fountain, J. C., Chen, Z. –Y., Scully, B. T., Kemerait, R. C., Lee, R. D., and Guo, B. Z. 2010. Comparison of PR-related gene expression in different maize genotypes. African Journal of Plant Science 4:433-440.

Brown, R. L., Chen, Z. -Y., Warburton, M., Luo, M., Menkir, A., Fakhoury, A., and Bhatnagar, D. 2010. Discovery and characterization of proteins associated with aflatoxin-resistance: evaluating their potential as breeding markers. Toxins 2:919-933.

Chen, Z. -Y.,  Brown, R. L., Cary, J. W., Damann, K. E., and Cleveland, T. E. 2009a. Characterization of an Aspergillus flavus alkaline protease and its role in the infection of maize kernels. J. Toxicology Toxin Review 28: 187-197.

Luo, M., Brown, R. L., Chen, Z. -Y., and Cleveland, T. E. 2009. Host genes involved in the interaction between Aspergillus flavus and maize. J. Toxicology, Toxin Reviews 28: 118-128.

Chen, Z. -Y., Brown, R. L., Guo, B. Z., Menkir, A., and Cleveland, T. E. 2009. Identifying aflatoxin resistance-related proteins/genes through proteomics and RNAi gene silencing. Peanut Science 36 (1): 35-41.

Baker, R. L., Brown, R. L., Chen, Z.-Y., Cleveland, T. E., and Fakhoury, A. M. 2009. A maize lectin-like protein with antifungal activity against Aspergillus flavus. J. Food Protection 72: 120-127.

Baker, R. L., Brown, R. L., Chen, Z.-Y., Cleveland, T. E., and Fakhoury, A. M. 2009. A maize trypsin inhibitor (ZmTIp) with limited activity against Aspergillus flavus. J. Food Protection 72: 185-188.

Park, S., Chen, Z.-Y., Chanda, A. K., Schneider, R. W., and Hollier, C. 2008. Viability of Phakopsora  pachyrhizi urediniospores under simulated southern Louisiana winter conditions. Plant Disease 92:1456-1462

Guo, B., Chen, Z.-Y., Lee, R. D., and Scully, B. T. 2008. Drought stress and preharvest aflatoxin contamination in agricultural commodity: genetics, genomics and proteomics. J. Integrative Plant Biology 50:1281-1291

Osiri, J. K., Shadpour, H., Park, S., Snowden, B. C., Chen, Z. -Y., and Soper, S. A. 2008. Generating high peak capacity 2-D maps of complex proteomes using PMMA microchip electrophoresis. Electrophoresis 29:4984-4992.

Cleveland, T. E. IV, Hussey, D. S., Chen, Z. -Y., Jacobson, D. L., Brown, R. L., Carter-Wientjes, C., Cleveland, T. E., and Arif, M. 2008. The use of neutron tomography for the structural analysis of corn kernels. J. Cereal Science 48:517-525.

Rajasekarana, K., Cary, J. W., Chen, Z. -Y., Brown, R. L., and Cleveland, T. E. 2008. Antifungal traits of a 14 kD maize kernel trypsin inhibitor protein in transgenic cotton. J. Crop Improvement 22:1-16.

Chen, Z. -Y., Brown, R. L., Damann, K. E., and Cleveland, T. E. 2007. Identification of maize kernel endosperm proteins associated with resistance to aflatoxin contamination by Aspergillus flavus. Phytopathology 97:1094-1103.

Brown, R. L., Chen, Z. -Y., Menkir, A., and Cleveland, T. E. 2006. Proteomics to identify resistance factors in corn-a review.  Mycotoxin Research 22:22-26.

Chen, Z. -Y., Brown, R. L., Rajasekaran, K., Damann, K. E., and Cleveland, T. E. 2006. Evidence for involvement of a pathogenesis-related protein in maize resistance to Aspergillus flavus infection /aflatoxin production.  Phytopathology 96:87-95.

Menkir, A., Brown, R. L., Bandyopadhyay, R., Chen, Z. -Y., and Cleveland, T. E. 2006. A U.S.A.-Africa collaborative strategy for identifying, characterizing, and developing maize germplasm with resistance to aflatoxin contamination. Mycopathologia 162:225-232.

Brown, R. L., Bhatnagar, D., Clveland, T. E., and Chen, Z.-Y. 2004. Molecular biology for control of mycotoxigenic fungi. Mycology 21:69-77.

Chen, Z. -Y., Brown, R. L., and Cleveland, T. E. 2004a. Evidence of an association between stress tolerance and host resistance in corn against Aspergillus flavus infection and aflatoxin contamination. African J. Biotechnol. 3:693-699.

Chen, Z. -Y., Brown, R. L., Damann, K. E., and Cleveland, T. E. 2004b. Identification of a maize kernel stress-related protein and its effect on aflatoxin accumulation. Phytopathology 94:938-945.

Cleveland, T. E., Yu, J., Bhatnagar, D., Chen, Z. -Y., Brown, R. L., Chang, P. K., and Cary, J. W. 2004. Elucidation of the molecular basis of the host plant-Aspergillus flavus interaction, a basis for devising strategies to reduce aflatoxin contamination in crops. J. Toxicology, Toxin Reviews 23:345-380.

Brown, R. L., Chen, Z. -Y., Menkir, A., and Cleveland, T. E. 2003. Using biotechnology to enhance host resistance to aflatoxin contamination of corn.  African J. Biotechnol. 2:557-562.

Banks, W. A., Niehoff, M. L., Brown, R. L., Chen, Z. -Y., and Cleveland, T. E. 2002. Transport across the blood-brain barrier of an antifungal trypsin inhibitor isolated from corn. Antimicrobial Agents and Chemotherapy 46:2633-2635.

Chen, Z. -Y., Brown, R. L., Damann, K. E., and Cleveland, T. E. 2002. Identification of unique or elevated levels of kernel proteins in aflatoxin-resistant maize genotypes through proteome analysis. Phytopathology 92:1084-1094.

Brown, R. L., Chen, Z. -Y., Cleveland, T. E., Cotty, P. J., and Cary, J. W. 2001. Variation in in vitro α-amylase and protease activity is related to the virulence of Aspergillus flavus isolates. J. Food Protection 64:401-404.

Brown, R. L., Chen, Z. -Y., Menkir, A., Cleveland, T. E., Cardwell, K., Kling, J. and White, D. G.  2001. Resistance to aflatoxin accumulation in kernels of maize inbreds selected for ear rot resistance in West and Central Africa. J. Food Protection 64:396-400.

Chen, Z. -Y., Brown, R. L., Cleveland, T. E., Damann, K. E., and Russin, J. S. 2001. Comparison of constitutive and inducible maize kernel proteins of genotypes resistant or susceptible to aflatoxin production. J. Food Protection 64:1785-1792.

Chen, Z. -Y., Brown, R. L., Lax, A. R., Cleveland, T. E., and Russin, J. S. 1999a. Inhibition of plant pathogenic fungi by a corn trypsin inhibitor over-expressed in Escherichia coli. Applied Environmental Microbiology 65:1320-1324.

Chen, Z. -Y., Brown, R. L., Russin, J. S., Lax, A. R., and Cleveland, T. E. 1999b. A corn trypsin inhibitor with antifungal activity inhibits Aspergillus flavus α-amylase. Phytopathology 89:902-907.

Brown, R. L., Chen, Z. -Y., Cleveland, T. E., and Russin, J. S. 1999. Advances in the development of host resistance to aflatoxin contamination by Aspergillus flavus. Phytopathology (review) 89:113-117.

Chen, Z. -Y., Brown, R. L., Lax, A. R., Guo, B. Z., Cleveland, T. E., and Russin, J. S. 1998. Resistance to Aspergillus flavus in corn kernels is associated with a 14 kDa protein. Phytopathology 88: 276-281.

Karlsson, J., Clarke, A. K., Chen, Z. -Y., Hugghins, S. Y., Park, Y.-II, Husic, H. D., Moroney, J. V., and Samuelsson, G.  1998. A novel α-type carbonic anhydrase associated with the thylakoid membrane in Chlamydomonas reinhardtii is required for growth at ambient CO₂. EMBO J. 17:1208-1216.

Moroney, J. V., and Chen, Z. -Y. 1998. The role of the chloroplast in inorganic carbon uptake by eukaryotic algae. Canadian Journal of Botany (review) 76:1025-1034.

Chen, Z. -Y., Lavigne, L. L., Mason, C. B. and Moroney, J. V. 1997. Cloning and overexpression of two cDNAs encoding the low-CO₂-inducible chloroplast envelope protein LIP-36 from Chlamydomonas reinhardtii. Plant Physiology 114: 256-273.

Guo, B. Z., Chen, Z. -Y., Brown, R. L., Lax, A. R., Cleveland, T. E., Russin, J. S., Mehta, A. D., Selitrennikoff,  C. P., and Widstrom, N. W. 1997. Germination induces accumulation of specific proteins and antifungal activities in corn kernels. Phytopathology 87:1174-1178.

Burow, M. D., Chen, Z. -Y., Mouton, T. M., and Moroney, J. V.  1996. Isolation of cDNA clones of genes induced upon transfer of Chlamydomonas reinhardtii cells to low CO₂. Plant Molecular Biology  31:443-448.

Chen, Z. -Y., Burow, M. D., Mason, C. B., and Moroney, J. V.  1996. A low CO₂ inducible gene encoding an alanine:alpha-ketoglutarate  aminotransferase in Chlamydomonas reinhardtii. Plant Physiology 112:677-684.

Chen, Z. -Y., and Moroney, J. V. 1995. Identification of a Chlamydomonas reinhardtii chloroplast gene with significant homology to bacterial genes involved in cytochrome c biosynthesis. Plant Physiology 108:843-844.

Refereed Conference Proceedings

Park, S., and Chen, Z. –Y. 2009. Investigating soybean-Phakopsora pachyrhizi interactions using proteomics. The 2009 World Soybean Research Conference VIII, August 14, 2009 (Beijing, China).

Cleveland, T. E., Rajasekaran, K., Cary, J. W., Chen, Z. -Y., Brown, R. L., Bhatnagar, D., and Radin, J. W. 2002. Balancing the possible risks and benefits of using biotechnology to enhance resistance in crops to Aspergillus flavus infection and aflatoxin contamination. In Pathogenic Microorganisms and Their Toxins: A Global Perspective of Their Risk (S. Yamamoto and W. P. Norred eds.) (Book Chapter). IXth International Symposium-U.S.-Japan Natural Resources Panel on Toxic Microorganisms (UNJR), pp. 268-301.

Moroney, J. V., Burow, M. D., Chen, Z. -Y., Borkhsenious, O. N., Mason, C. B., and Somanchi, A. 1998. Adaptation of Chlamydomonas reinhardtii to limiting CO₂ conditions. In Photosynthesis: Mechanisms and Effects. Vol V, Ed. by G. Garab, Kluwer Academic Publishers, Dordrecht, pp. 3443-3446.

Chen, Z. -Y., Burow, M. D., and Moroney, J. V. 1995. Characterization of genes induced by low CO₂ in Chlamydomonas reinhardtii. Photosynthesis: from Light to Biosphere, (P. Mathis ed.), Kluwer Academic Publishers, Vol. V: 619-622.

Refereed Book Chapters

Brown, R.L., Menkir, A., Chen, Z.-Y., Luo, M., and Bhatnagar, D. 2011. Identification of gene markers in aflatoxin-resistant maize germplasm for marker-assisted breeding. In Aflatoxins-Biochemistry and Molecular Biology  (Ed. R. G. Guevara-Gonzalez), InTech, Rijeka, Croatia, pp. 91--106.

Brown, R.L., Chen, Z.-Y., Menkir, A., Cleveland, T.E., and Bhatnagar, D. 2008. Strategies for the prevention of preharvest aflatoxin contamination of maize. In Recent Advancement in Agriculture  (Eds. C. Stevens and V. A. Khan), Research Signpost, Kerala, India, pp. 131-150.

Brown, R. L., Chen, Z. -Y., Menkir, A., Cleveland, T. E., and Bhatnagar, D. 2008. Application of biotechnology towards enhancement of maize resistance to aflatoxin contamination by Aspergillus flavus. In Crop Improvement and Biochnology (Eds. D. Thangadurai, L. Tripathi, H.K.N. Vasanthaiah, and D.J. Cantu), Bioscience Publications, India, pp. 57-67.

Menkir, A., Brown, R. L., Bandyopadhyay, R., Chen, Z. -Y., and Cleveland, T. E. 2008.  Breeding maize for resistance to mycotoxins at IITA. In Mycotoxins: Detection Methods, Management, Public Health and Agricultural Trade (Ed. J. F. Leslie), CABI Publishing, pp. 277-289.

Chen, Z. -Y.,  Rajasekaran, K., Brown, R. L., Bhatnagar D., and Cleveland, T. E. 2006. Removal of aflatoxin contamination from food and feed crops. In Plant Genetic Engineering Vol. 8: Metabolic Engineering and Molecular Farming II (Eds. P. K. Jaiwal and R. P. Singh). Studium Press, Houston, TX, pp. 73-110.

Brown, R. L., Chen, Z. -Y., Cleveland, T. E., and Bhatnagar, D. 2005. Molecular aspects of corn resistance mechanisms against aflatoxigenic fungi. In Genetic Resources and Biotechnology, Vol II (Eds. D. Thangadurai, T. Pullaiah and P. A. Balatti), Regency Publications, New Delhi, India, pp. 281-294.

Cleveland, T. E., Yu, J., Bhatnagar, D. Chen, Z. -Y., Brown, R. L., Chang, P.-K., and Cary, J. W. 2005. Progress in elucidating the molecular basis of the host plant-Aspergillus flavus interaction: A basis for devising strategies to reduce aflatoxin contamination in crops. In Aflatoxin and Food Safety (Ed. H. Abbas), CRC Press, Boca Raton, FL, pp. 167-193.

Rajasekaran, K., Bhatnagar, D., Brown, R. L., Chen, Z. -Y, Cary, J. W., and Cleveland, T. E. 2005. Enhancing Food Safety: prevention of preharvest aflatoxin contamination. In Perspectives of Agricultural Research and Development (Eds. C. Ramasamy, S. Ramanathan, and M. Dhakshinamoorthy), Tamil Nadu Agricultural University, Coimbatore, India, pp. 434-467.

Brown, R. L., Chen, Z. -Y., Bhatnagar, D., and Cleveland, T.E. 2004. Molecular biology for control of mycotoxigenic fungi. In Fungal Biotechnology in Agricultural, Food, and Environmental Application, (Eds. D. Arora, P. Bridge, and D. Bhatnagar). Marcel Dekker, Inc. New York, pp. 69-77.

Brown, R. L., Chen, Z. -Y., Gembeh, S. V., Cleveland, T. E., Bhatnagar, D., and Howard, K. 2004. Identification of natural resistance in corn against mycotoxin-producing fungi. In Research Advances in Food Science (Ed. R. M. Mohan), Global Research Network, Kerala, India, pp. 85-96.

Chen, Z. -Y., Cleveland, T. E., Brown, R. L., Bhatnagar, D., Cary, J. W., and Rajasekaran, K. 2002. Corn as a source of antifungal genes for genetic engineering of crops for resistance to aflatoxin contamination. In Crop Biotechnology (Eds. K. Rajasekaran, J. W. Finley, and  T. J. Jacks), ACS Symposium Series No. 829, American Chemical Society, Washington, DC, pp. 131-150.

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